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Abstract #0649

Variations of quantitative MRI metrics along the cervical spinal cord: multi-vendor, multi-center, multi-subject study

Jan Valošek1,2 and Julien Cohen-Adad2,3
1Department of Neurology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic, 2NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 3Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada

Quantitative MRI (qMRI) of the spinal cord (SC), such as diffusion-weighted and magnetic transfer imaging can be used in diagnosis of many different diseases. In this study, we established normative qMRI metrics along C2-C5 cervical SC levels for different regions-of-interest (spinal cord, white and gray matter, white matter columns) for 3 major MRI vendors (Siemens, Philips, GE) in large open-access dataset of ~250 healthy subjects. Metrics showed dependency on vertebral levels and confirmed different microstructural organization along SC. Moreover, differences in qMRI metrics were observed between individual vendors suggesting the influence of different MRI scanner configurations.

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