Abstract #0675

Hyperpolarized 13C MRI reveals age-related changes in lactate metabolism in the human brain

Biranavan Uthayakumar^1,2, Casey Y Lee^1,2, Nadia Bragagnolo^1,2, Hany Soliman³, Albert P Chen⁴, Ruby Endre⁵, William J Perks², Chris Heyn⁶, Sandra E Black², and Charles Cunningham⁷

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Radiation oncolocy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴GE Healthcare, Toronto, ON, Canada, ⁵Physical sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Medical Biophysics, Sunnybrook research institute, Toronto, ON, Canada

In this study, hyperpolarized ¹³C MRI was used to investigate age-related changes to lactate and bicarbonate production in the brain in a healthy aging population. A whole-brain parcellation method was used to investigate regional changes. A global reduction in the production of both ¹³C-lactate and ¹³C-bicarbonate was observed vs. age, with certain regions showing increased rates of change in comparison to the rest of the brain. Our results suggest an age-related change in the underlying metabolic processes, and paves the way for future analysis of pathological aging as seen in disorders like Alzheimer's disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here