Abstract #0675

Hyperpolarized 13C MRI reveals age-related changes in lactate metabolism in the human brain

Biranavan Uthayakumar^1,2, Casey Y Lee^1,2, Nadia Bragagnolo^1,2, Hany Soliman³, Albert P Chen⁴, Ruby Endre⁵, William J Perks², Chris Heyn⁶, Sandra E Black², and Charles Cunningham⁷

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Radiation oncolocy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴GE Healthcare, Toronto, ON, Canada, ⁵Physical sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Medical Biophysics, Sunnybrook research institute, Toronto, ON, Canada

In this study, hyperpolarized ¹³C MRI was used to investigate age-related changes to lactate and bicarbonate production in the brain in a healthy aging population. A whole-brain parcellation method was used to investigate regional changes. A global reduction in the production of both ¹³C-lactate and ¹³C-bicarbonate was observed vs. age, with certain regions showing increased rates of change in comparison to the rest of the brain. Our results suggest an age-related change in the underlying metabolic processes, and paves the way for future analysis of pathological aging as seen in disorders like Alzheimer's disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.