Meeting Banner
Abstract #0679

Hyperpolarized δ-[1-13C]gluconolactone detects response to chemotherapy in brain tumors in vivo

Georgios Batsios1, Celine Taglang1, Anne Marie Gillespie1, Peder Larson1, Sabrina M Ronen1, and Pavithra Viswanath1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

Glucose metabolism via the pentose phosphate pathway (PPP) is typically upregulated in tumors, including gliomas. We previously showed that hyperpolarized δ-[1-13C]gluconolactone metabolism via the PPP to 6-phospho-[1-13C]gluconate (6PG) differentiates tumor from contralateral normal brain in preclinical glioma models. Here, we examined the ability of hyperpolarized δ-[1-13C]gluconolactone to probe response to temozolomide, which is a key chemotherapeutic drug for glioma patients. Our studies in live cells and rats bearing orthotopic gliomas indicate that 6PG production from hyperpolarized δ-[1-13C]gluconolactone serves as an early biomarker of response to temozolomide, a finding that has the potential to improve treatment response monitoring for glioma patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here