Abstract #0678

Hyperpolarized 13C MRI Detects In-Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle

Jun Chen¹, Junjie Ma¹, Crystal E Harrison¹, James Ratnakar¹, Zungho Zun², Jeff Liticker¹, Galen D Reed³, Avneesh Chhabra⁴, Thomas Jue⁵, Craig R Malloy^1,3,6, and Jae Mo Park^1,4,7

¹AIRC, UT Southwestern Medical Center, Dallas, TX, United States, ²The Developing Brain Institute, Children’s National Hospital, Washington, DC, United States, ³GE, Chicago, IL, United States, ⁴Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Biochemistry and Molecular Medicine, UC Davis, Davis, CA, United States, ⁶Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁷Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States

Pyruvate dehydrogenase (PDH) and lactate dehydrogenase (LDH) are essential for ATP production in skeletal muscle. However, directly PDH flux in exercising human muscle has been challenging and never assessed. This study was to demonstrate the feasibility of assessing PDH activation and changes in pyruvate metabolism in human skeletal muscle after the onset of exercise using hyperpolarized [1-13C]pyruvate. During moderate flexion-extension exercise, total HP 13C signals (tC), [1-13C]lactate/tC, and [13C]bicarbonate/tC increased significantly compared to resting state. This study demonstrates that PDH flux in skeletal muscle increases rapidly after the onset of exercise and decreases during recovery.

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