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Abstract #0678

Hyperpolarized 13C MRI Detects In-Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle 

Jun Chen1, Junjie Ma1, Crystal E Harrison1, James Ratnakar1, Zungho Zun2, Jeff Liticker1, Galen D Reed3, Avneesh Chhabra4, Thomas Jue5, Craig R Malloy1,3,6, and Jae Mo Park1,4,7
1AIRC, UT Southwestern Medical Center, Dallas, TX, United States, 2The Developing Brain Institute, Children’s National Hospital, Washington, DC, United States, 3GE, Chicago, IL, United States, 4Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 5Biochemistry and Molecular Medicine, UC Davis, Davis, CA, United States, 6Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 7Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States

Pyruvate dehydrogenase (PDH) and lactate dehydrogenase (LDH) are essential for ATP production in skeletal muscle. However, directly PDH flux in exercising human muscle has been challenging and never assessed. This study was to demonstrate the feasibility of assessing PDH activation and changes in pyruvate metabolism in human skeletal muscle after the onset of exercise using hyperpolarized [1-13C]pyruvate. During moderate flexion-extension exercise, total HP 13C signals (tC), [1-13C]lactate/tC, and [13C]bicarbonate/tC increased significantly compared to resting state. This study demonstrates that PDH flux in skeletal muscle increases rapidly after the onset of exercise and decreases during recovery.

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