Meeting Banner
Abstract #0677

Characterization of glycolytic phenotypes using hyperpolarized 13C-MR and [18F]FDG PET in endogenous T-cell lymphomas in mice

Frits H.A. van Heijster1, Jason G. Skinner1, Tim Wartewig2, Christian Hundshammer1, Martin Grashei1, Geoffrey J. Topping1, Erik Hameister2, Jürgen Ruland2, and Franz Schilling1
1Technical University Munich, Nuclear Medicine, Klinikum rechts der Isar, München, Germany, 2Technical University Munich, TranslaTUM, Center for Translational Cancer Research, München, Germany

High- and low- glycolytic phenotypes of murine T-cell lymphoma are characterized using hyperpolarized MR spectroscopy/imaging and [18F]FDG-PET. Differences in pyruvate-to-lactate conversion are found within tumor groups, where PET imaging did not show this distinction. Using tumor metabolic volumes derived from PET imaging on the other hand, it’s possible to distinguish between low- and high-grade tumors. The complementary information of the two modalities gives a more complete view of the characteristics of the glycolytic phenotypes in T-cell lymphoma.

This abstract and the presentation materials are available to members only; a login is required.

Join Here