Abstract #0677

Characterization of glycolytic phenotypes using hyperpolarized 13C-MR and [18F]FDG PET in endogenous T-cell lymphomas in mice

Frits H.A. van Heijster¹, Jason G. Skinner¹, Tim Wartewig², Christian Hundshammer¹, Martin Grashei¹, Geoffrey J. Topping¹, Erik Hameister², Jürgen Ruland², and Franz Schilling¹

¹Technical University Munich, Nuclear Medicine, Klinikum rechts der Isar, München, Germany, ²Technical University Munich, TranslaTUM, Center for Translational Cancer Research, München, Germany

High- and low- glycolytic phenotypes of murine T-cell lymphoma are characterized using hyperpolarized MR spectroscopy/imaging and [¹⁸F]FDG-PET. Differences in pyruvate-to-lactate conversion are found within tumor groups, where PET imaging did not show this distinction. Using tumor metabolic volumes derived from PET imaging on the other hand, it’s possible to distinguish between low- and high-grade tumors. The complementary information of the two modalities gives a more complete view of the characteristics of the glycolytic phenotypes in T-cell lymphoma.

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