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Abstract #0681

Extension of a Diagnostic Model for Pulmonary Hypertension with Hyperpolarized 129Xe Magnetic Resonance Imaging and Spectroscopy

Elianna Ada Bier1, Fawaz Alenezi2, Junlan Lu3, Joseph G Mammarappallil4, Bastiaan Driehuys4, and Sudarshan Rajagopal2
1Biomedical Engineering, Duke University, Durham, NC, United States, 2Division of Cardiology, Department of Medicine, Duke Univeristy, Durham, NC, United States, 3Medical Physics Graduate Program, Duke University, Durham, NC, United States, 4Radiology, Duke University, Durham, NC, United States

129Xe dynamic spectroscopy combined with 129Xe gas exchange MRI can detect both pre- and postcapillary pulmonary hypertension (PH). However, reliance on whole lung spectroscopy limits this technique’s ability to detect spatially heterogeneous impacts of PH. For example, the algorithm cannot identify combined pre- and postcapillary PH (CpcPH) and does not currently account for out-of-proportion PH in patients with parenchymal disease. Here we use the recently introduced method of imaging signal oscillations from 129Xe in red blood cells to gain additional insights into 26 subjects who have also undergone right heart catheterization to determine PH status within 2 months of imaging.

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