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Abstract #0682

Pulmonary acinar structure and function assessed by hyperpolarized 129Xe stimulated echo NMR

Agilo Luitger Kern1,2, Marcel Gutberlet1,2, Frank Wacker1,2, Jens Hohlfeld2,3,4, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 4Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

A pulse sequence for hyperpolarized 129Xe NMR based on accumulated stimulated echoes has been implemented. Pairs of 90° pulses are repeatedly irradiated at the frequency of 129Xe in tissue-plasma and the decaying signal transferred to the gas phase is subsequently acquired. A study with healthy volunteers and patients of chronic obstructive pulmonary disease (COPD) has been performed to assess the method’s sensitivity for disease. A significant reduction of initial stimulated echo signal and trend for faster decay are observed in COPD. The proposed method has been demonstrated to be highly sensitive for emphysema and hyperinflation and shows promising diagnostic potential.

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