Abstract #0682

Pulmonary acinar structure and function assessed by hyperpolarized 129Xe stimulated echo NMR

Agilo Luitger Kern^1,2, Marcel Gutberlet^1,2, Frank Wacker^1,2, Jens Hohlfeld^2,3,4, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, ⁴Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

A pulse sequence for hyperpolarized ¹²⁹Xe NMR based on accumulated stimulated echoes has been implemented. Pairs of 90° pulses are repeatedly irradiated at the frequency of ¹²⁹Xe in tissue-plasma and the decaying signal transferred to the gas phase is subsequently acquired. A study with healthy volunteers and patients of chronic obstructive pulmonary disease (COPD) has been performed to assess the method’s sensitivity for disease. A significant reduction of initial stimulated echo signal and trend for faster decay are observed in COPD. The proposed method has been demonstrated to be highly sensitive for emphysema and hyperinflation and shows promising diagnostic potential.

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