Abstract #0684

Preclinical Hyperpolarized 129Xe Ventilation Imaging Using 3D Spiral (FLORET) Encoding

Brice J Albert¹, Peter J Niedbalski¹, and Zackary I Cleveland^1,2,3,4

¹Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, United States, ⁴Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States

Center-out trajectories are often used in preclinical HP gas MRI to reduce the impact of physiological motion and magnetization decay on image quality. Recently, implementation of 3D spiral (FLORET) imaging for human ¹²⁹Xe ventilation imaging demonstrated higher accuracy in detecting ventilation abnormalities than traditional sequences. Here we show FLORET sequences provide superior SNR, consume less xenon, and reduce scan time by more than five times when used to image ventilation in mice.

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