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Abstract #0685

Myofiber strain in healthy humans using cDTI and Cine DENSE MRI

Kevin Moulin1,2,3, Pierre Croisille4,5, Magalie Viallon4,5, Ilya A Verzhbinsky6, Luigi E Perotti7, and Daniel B Ennis1,2,3
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Cardiovascular Institute, Stanford University, Stanford, CA, United States, 4University of Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint-Etienne, France, 5Department of Radiology, University Hospital Saint-Etienne, Saint-Etienne, France, 6Medical Scientist Training Program, University of California - San Diego, La Jolla, CA, United States, 7Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL, United States

Despite the importance of myofiber strain (Eff) to overall heart function, it has remained very difficult to measure Eff in vivo owing to the challenges of measuring both microstructural and functional cardiac data. We propose a new method that integrates cDTI and a volume of short- and long-axis DENSE slices with 2D displacement encoding to enable the measurement of in vivo Eff in humans. The accuracy of the approach for measuring Eff was evaluated in silico. Finally, in vivo Eff values were measured and reported for thirty (N=30) healthy volunteers for which an average Eff=-0.14 was found.

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