Abstract #0687

Probing Human Myocardial Krebs Cycle Metabolism and Response to Glucose Challenge using Hyperpolarized [2-13C]Pyruvate MR Spectroscopy

Hsin-Yu Chen¹, Jeremy W. Gordon¹, Nicholas Dwork¹, Brian T. Chung¹, Andrew Riselli², Robert A. Bok¹, James B. Slater¹, M. Roselle Abraham³, Daniel B. Vigneron¹, and Peder E.Z. Larson¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²School of Pharmacy, University of California, San Francisco, San Francisco, CA, United States, ³Department of Medicine-Cardiology, University of California, San Francisco, San Francisco, CA, United States

This study explored the safety and feasibility to visualize real-time myocardial Krebs cycle energetics in healthy volunteers using hyperpolarized [2-¹³C]pyruvate MR spectroscopy, and to investigate the response to oral glucose challenge. Identified metabolic products included [2-¹³C]lactate, Krebs cycle-related intermediate [5-¹³C]glutamate, and [1-¹³C]acetylcarnitine, a key player in the “carnitine shuttle” of mitochondrial fatty acid oxidation. Upon oral glucose challenge, the levels of all three products increased, illustrating the metabolic flexibility of human heart to switch between fatty acid and carbohydrates.

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