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Abstract #0697

Biomimetic phantoms of impeded diffusion in prostate cancer using lipid nanoparticles

Scott D. Swanson1, Thomas L. Chenevert1, Prasad R. Shankar1, Ted Lynch2, and Dariya I. Malyarenko1
1Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 2CIRS, Norfolk, VA, United States

PI-RADS guidelines use quantitative mono-exponential apparent diffusion coefficient (ADC) for risk stratification of small potentially aggressive prostate cancer (PCa). Inherently, multi-exponential diffusion in complex tumor microenvironment, limits accuracy of ADC-based thresholds and clinical utility of DWI acquisition protocols. Biomimetic phantoms that provide ground-truth diffusion parameters help establish accuracy of advanced multi-b DWI protocols and parametric diffusion models in prostate tumors. This work demonstrates development of stable phantoms based on lipid nanoparticles that provide diffusion parameter ranges typical of PCa.

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