Abstract #0706

Volumetric fetal flow imaging with rapid multislice multidimensional radial phase contrast MRI

Datta Singh Goolaub^1,2, Jiawei Xu³, Eric Schrauben⁴, Davide Marini⁵, Mike Seed^5,6, and Christopher Macgowan^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Pediatric Cardiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Department of Pediatrics, University of Toronto, Toronto, ON, Canada

In this study, we demonstrate multidimensional fetal blood flow visualization and quantification, using highly accelerated multislice radial phase contrast MRI with slice-to-volume reconstruction. This acquisition and analysis pipeline provides real-time reconstructions for in-plane motion correction and cardiac gating for subsequent CINE reconstruction. CINEs are combined into a dynamic flow sensitive volume using slice-to-volume reconstruction with interslice motion correction. Experimental validation is presented in two adult volunteers. Feasibility is demonstrated in four human fetuses capturing complex hemodynamics in the fetal circulation.

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