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Abstract #0706

Volumetric fetal flow imaging with rapid multislice multidimensional radial phase contrast MRI

Datta Singh Goolaub1,2, Jiawei Xu3, Eric Schrauben4, Davide Marini5, Mike Seed5,6, and Christopher Macgowan1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 3Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, ON, Canada, 4Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Pediatric Cardiology, The Hospital for Sick Children, Toronto, ON, Canada, 6Department of Pediatrics, University of Toronto, Toronto, ON, Canada

In this study, we demonstrate multidimensional fetal blood flow visualization and quantification, using highly accelerated multislice radial phase contrast MRI with slice-to-volume reconstruction. This acquisition and analysis pipeline provides real-time reconstructions for in-plane motion correction and cardiac gating for subsequent CINE reconstruction. CINEs are combined into a dynamic flow sensitive volume using slice-to-volume reconstruction with interslice motion correction. Experimental validation is presented in two adult volunteers. Feasibility is demonstrated in four human fetuses capturing complex hemodynamics in the fetal circulation.

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