Abstract #0707

Longitudinal Placental Blood Volume Measurements on Zika-Infected Rhesus Macaques Using Variable Flip Angle T1 Mapping

Ruiming Chen¹, Sydney Nguyen^2,3,4, Megan E. Murphy^2,3,4, Kathleen M. Anthony^2,3,4, Terry K. Morgan⁵, Philip Corrado¹, Sean B. Fain^1,6, Dinesh M. Shah⁷, Ronald R. Magness⁸, Thaddeus Golos^2,3,4, Oliver Wieben^1,6,9, and Kevin M. Johnson^1,9

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ³Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Pathology, Oregon Health & Science University, Portland, OR, United States, ⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁷Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁸Obstetrics and Gynecology, University of South Florida, Tampa, FL, United States, ⁹Radiology, University of Wisconsin - Madison, Madison, WI, United States

Adequate maternal blood supply is an important factor to maintain placental health, and placenta vascular markers may be predictive of pregnancy outcomes. Here, we report longitudinal quantitative results of maternal fractional, regional, and total blood volume measurements in rhesus macaque placenta across gestation ages using Ferumoxytol-enhanced variable flip angle (VFA)-T1 mapping. We observe regional heterogeneity in fractional blood volume and increased maternal placental blood volume throughout pregnancy.

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