Abstract #0708

Velocity-Selective Arterial Spin Labeling Perfusion Measurements in 2nd Trimester Human Placenta with Varying BMI

Daniel Seiter¹, Ruiming Chen¹, Kai Ludwig¹, Ante Zhu², Dinesh Shah³, Oliver Wieben^1,4, and Kevin Johnson^1,4,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²GE Global Research, Niskayuna, NY, United States, ³Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Madison-Wisconsin, Madison, WI, United States

Proper placental development is crucial to fetal health. To the best of our knowledge, we report the earliest measurement of perfusion in the human placenta using velocity-selective arterial spin labeling (VS-ASL) MRI. Patients were scanned at 14- and 20-weeks gestation (term is 40 weeks) and clinical data was collected. Regression analysis shows no evidence for an increase in placental perfusion with gestational age, but strong evidence of an increase in perfusion with patient body mass index (BMI).

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