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Abstract #0709

Detecting abnormal placental microvascular flow based on flow-compensated and non-compensated intravoxel incoherent motion imaging

Yuhao Liao1, Taotao Sun2,3, Ling Jiang2,3, Zhiyong Zhao1, Tingting Liu1, Zhaoxia Qian2,3, Yi Sun4, Yi Zhang1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China, 4MR Collaboration, Siemens Healthcare China, Shanghai, China

Intravoxel Incoherent Motion (IVIM) imaging has been used to assess placental microcirculatory flow for prenatal examination. Here we proposed a joint analysis of flow-compensated (FC) and non-compensated (NC) diffusion MRI to estimate the fraction and velocity of ballistic microcirculatory flow, and evaluated the diagnostic performance of the new IVIM markers in maternal and fetal disorders. We found the flow velocity measurement from FC-NC joint model could differentiate patients with maternal hyperglycemia and fetal growth restriction compared to the controls, while the conventional IVIM parameters based on bi-exponential model using FC-only or NC-only data could not show the group difference.

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