Abstract #0715

Dynamic GlucoCEST MRI: results in primary brain tumors at 3 Tesla

REGIS OTAVIANO FRANCA BEZERRA¹, Hae Won Lee², Gustavo Kaneblai³, Eduardo Figueiredo³, Mitsuharu Miyoshi⁴, Thomas Doring³, Claudia da Costa Leite⁵, Giovanni Guido Cerri², and Frederico Perego Costa⁶

¹RADIOLOGY, HOSPITAL SÍRIO-LIBANÊS, SAO PAULO, Brazil, ²Radiology, Hospital Sírio-Libanês, Sao Paulo, Brazil, ³General Eletric, Sao Paulo, Brazil, ⁴General Eletric, Tokyo, Japan, ⁵RADIOLOGIA, HOSPITAL SÍRIO-LIBANÊS, SAO PAULO, Brazil, ⁶Oncology, Hospital Sírio-Libanês, Sao Paulo, Brazil

This study shows the glucoCEST effect in 15 patients with primary malignant brain tumors compared with normal white matter(NWM) at 3-Tesla-MRI. The procedure included a full Z-spectra CEST and a dynamic glucoCEST. The signal % at 2 ppm calculated using mean asymmetric magnetization transfer ratio values were significantly higher in the whole cancer compared to NWM. Similarly, the dynamic glucoCEST presented as mean area-under-the-curve values were significantly different in whole cancer in comparison to normal tissue. This method, using clinical field strength of 3Tesla, was capable of identifying distinct patterns of glucose metabolismand also heterogeneity in the cancer metabolism

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