We study the effect of macromolecular proton fraction (MPF) and R1 interdependency in quantitative MT experiments. We hypothesize that the two-pool model with properly calibrated relaxation constraints on the bound proton pool can separate interdependency of both metrics, potentially improving the specificity of both, specifically, MPF to macromolecular content and R1 to paramagnetic ions. The simulation and in vivo results support feasibility of such refinement.
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