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Abstract #0716

Confounding of Macromolecular and Paramagnetic Tissue Content in Quantitative MTI Remedied by Explicit Estimation of Bound Pool Relaxation

Alexey Samsonov1 and Aaron S. Field1
1Radiology, University of Wisconsin-Madison, Madison, WI, United States

We study the effect of macromolecular proton fraction (MPF) and R1 interdependency in quantitative MT experiments. We hypothesize that the two-pool model with properly calibrated relaxation constraints on the bound proton pool can separate interdependency of both metrics, potentially improving the specificity of both, specifically, MPF to macromolecular content and R1 to paramagnetic ions. The simulation and in vivo results support feasibility of such refinement.

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