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Abstract #0717

Improved volumetric inhomogeneous magnetization transfer (ihMT) using a CSF-suppressed FSE sequence (FLAIR-ihMT)

Manuel Taso1, Fanny Munsch1, Olivier M Girard2, Guillaume Duhamel2, David C Alsop1, and Gopal Varma1
1Division of MRI research, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2CRMBM, Aix-Marseille Univ, CNRS, Marseille, France

3D myelin imaging using inhomogeneous magnetization transfer (ihMT) has seen increased interest as sequence implementations evolve. This has mostly been based on prepared or pseudo-steady-state gradient echo sequences. However, Fast-Spin-Echo (FSE) sequences should have a theoretical SNR advantage over GRE. Here we report implementation of a CSF-suppressed FSE sequence for ihMT imaging (FLAIR-ihMT), exploring through simulations the effect of CSF suppression and providing first imaging results, highlighting the benefits of CSF suppression, potential for whole brain high-resolution imaging and translation down to the spinal cord.

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