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Abstract #0718

Inhomogeneous magnetization transfer in the healthy adult brain: reproducibility and correlation with MTR and myelin water imaging

Sarah Rosemary Morris1,2,3, Irene M. Vavasour1,4, Anastasia Smolina5,6, Erin MacMillan4,7, Guillaume Gilbert7, Michelle Lam2,4, Piotr Kozlowski1,2,4,8, Carl Michal2, Alan Manning2, Alex L. MacKay1,2,4, and Cornelia Laule1,2,4,8,9
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Physics & Astronomy, McMaster University, Hamilton, ON, Canada, 6Hospital for Sick Children, Toronto, ON, Canada, 7MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 8International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 9Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

We compared three myelin-sensitive MRI metrics (inhomogeneous magnetization transfer ratio (ihMTR), magnetization transfer ratio (MTR) and gradient and spin echo-derived myelin water fraction (MWF)) in 15 white matter regions of interest from 14 healthy adults at 3T. Reproducibility of ihMTR was also investigated. We found a moderately strong correlation between MWF and ihMTR but only a very weak correlation between MWF and MTR. Myelination rankings were similar for ihMTR and MWF but had no relation to MTR. Finally, we established an average ihMTR scan-rescan variability of 8.2% of the mean in each ROI.

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