Abstract #0718

Inhomogeneous magnetization transfer in the healthy adult brain: reproducibility and correlation with MTR and myelin water imaging

Sarah Rosemary Morris^1,2,3, Irene M. Vavasour^1,4, Anastasia Smolina^5,6, Erin MacMillan^4,7, Guillaume Gilbert⁷, Michelle Lam^2,4, Piotr Kozlowski^1,2,4,8, Carl Michal², Alan Manning², Alex L. MacKay^1,2,4, and Cornelia Laule^1,2,4,8,9

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴UBC MRI Research Centre, Vancouver, BC, Canada, ⁵Physics & Astronomy, McMaster University, Hamilton, ON, Canada, ⁶Hospital for Sick Children, Toronto, ON, Canada, ⁷MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ⁸International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ⁹Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

We compared three myelin-sensitive MRI metrics (inhomogeneous magnetization transfer ratio (ihMTR), magnetization transfer ratio (MTR) and gradient and spin echo-derived myelin water fraction (MWF)) in 15 white matter regions of interest from 14 healthy adults at 3T. Reproducibility of ihMTR was also investigated. We found a moderately strong correlation between MWF and ihMTR but only a very weak correlation between MWF and MTR. Myelination rankings were similar for ihMTR and MWF but had no relation to MTR. Finally, we established an average ihMTR scan-rescan variability of 8.2% of the mean in each ROI.

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