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Abstract #0720

CEST Imaging of Nose-to-Brain Drug Delivery using Iohexol liposomes at 3T

Lok Hin LAW1, Peng XIAO1, Jianpan Huang1, Xiongqi HAN1, and Kannie WY CHAN1,2,3
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

Imaging-guided nose-to-brain drug delivery provide a non-invasive monitoring of drug delivery to brain, which increases effective dose via bypassing Blood-Brain-Barrier(BBB). Here, we investigated imaging of nanomedicine delivery via intranasal-administration using CEST-detectable mucus-penetrating-liposome(with 10%PEG). Liposomes were loaded with Iohexol(Ioh-Lipo) and CEST properties were examined both in-vitro and in-vivo by injecting into mouse nostril. Ioh-Lipo generated CEST contrast of 33.4% at 4.3 ppm in-vitro. which was also observed in nostril, olfactory-bulb and frontal-lobe after intranasal-administration at 3T. We demonstrated the liposomes detectability both in nostril and olfactory-bulb by CEST. The result demonstrates an approach for imaging-guided Nose-to-Brain Intranasal Liposomal Drug Delivery.

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