Abstract #0721

Peritumoral radiomics features from amide proton transfer-weighted MRI unveil the progressive pattern in early recurrent malignant gliomas

Shanshan Jiang¹, Pengfei Guo², Hye Young Heo¹, Peter van Zijl^1,3, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Assessing post-treatment malignant gliomas early has remained one of the most critical dilemmas in neuro-oncology for three decades. Amide protein transfer weighted (APTw) MRI has been validated to accurately detect recurrent malignant gliomas in more and more studies. The peritumoral area, as the one of the most aggressive regions, has been seldom studied. Here, we explore radiomics features extracted from peritumoral areas on APTw images to unveil the progressive pattern in early recurrent malignant gliomas. Our results suggest that the use of APTw radiomic features can add important value to structural MRI to assess the treatment response.

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