Abstract #0722

Deuterium metabolic imaging of tumor burden and response to therapy in mutant IDH gliomas in vivo

Celine Taglang¹, Georgios Batsios¹, Mers Tran¹, Anne Marie Gillespie¹, Hema Artee Luchman², Russell O Pieper³, Sabrina M Ronen¹, and Pavithra Viswanath¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Cell Biology and Anatomy, University of Calgary and Hotchkiss Brain Institute, Calgary, AB, Canada, ³Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

²H-magnetic resonance spectroscopy (MRS) recently emerged as a novel, non-invasive method of monitoring metabolic fluxes in high-grade glioblastomas in vivo. However, its utility for imaging low-grade gliomas and for assessing treatment response has not been examined. Here, we show that [6,6’-²H]-glucose metabolism to lactate serves to delineate tumor from contralateral normal brain in mice bearing orthotopic patient-derived low-grade glioma xenografts. Importantly, reduced lactate production from [6,6’-²H]-glucose informs on early response to therapy, at timepoints when volumetric alterations cannot be detected by anatomical imaging, pointing to the ability of [6,6’-²H]-glucose to assess pseudoprogression, which is a major challenge in glioma imaging.

This abstract and the presentation materials are available to members only; a login is required.

Join Here