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Abstract #0723

CRT-FID-MRSI at 7T for the high-resolution metabolic imaging of epilepsy: Preliminary results

Gilbert Hangel1, Philipp Lazen2, Matthias Tomschik1, Jonathan Wais1, Eva Hečková2, Lukas Hingerl2, Stephan Gruber2, Bernhard Strasser2, Gregor Kasprian3, Daniela Prayer3, Julia Furtner3, Christoph Baumgartner4, Johannes Koren4, Robert Diehm5, Martha Feucht5, Christian Dorfer1, Ekaterina Pataraia6, Wolfgang Bogner2, Siegfried Trattnig2,7, and Karl Rössler1
1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 2High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Department of Neurology, Clinic Hietzing, Vienna, Austria, 5Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, 6Department of Neurology, Medical University of Vienna, Vienna, Austria, 7Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

We successfully implemented a fast high-resolution 3D-MRSI protocol covering the whole brain at 7T in a preliminary study of 14 patients with pharmacoresistant epilepsy. With an isotropic resolution of 3.4 mm acquired in 15:30 min, we detected focal metabolic alterations in thirteen patients. From all metabolites, tCr, Glu, mIns and NAA and especially tCho appear as the most relevant markers for detection of focal metabolic alterations in epilepsy. Especially concerning cortical developmental alterations as a cause of epilepsy, our findings may have the potential to differentiate metabolic fingerprints for FCD subclasses.

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