Abstract #0723

CRT-FID-MRSI at 7T for the high-resolution metabolic imaging of epilepsy: Preliminary results

Gilbert Hangel¹, Philipp Lazen², Matthias Tomschik¹, Jonathan Wais¹, Eva Hečková², Lukas Hingerl², Stephan Gruber², Bernhard Strasser², Gregor Kasprian³, Daniela Prayer³, Julia Furtner³, Christoph Baumgartner⁴, Johannes Koren⁴, Robert Diehm⁵, Martha Feucht⁵, Christian Dorfer¹, Ekaterina Pataraia⁶, Wolfgang Bogner², Siegfried Trattnig^2,7, and Karl Rössler¹

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department of Neurology, Clinic Hietzing, Vienna, Austria, ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Neurology, Medical University of Vienna, Vienna, Austria, ⁷Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

We successfully implemented a fast high-resolution 3D-MRSI protocol covering the whole brain at 7T in a preliminary study of 14 patients with pharmacoresistant epilepsy. With an isotropic resolution of 3.4 mm acquired in 15:30 min, we detected focal metabolic alterations in thirteen patients. From all metabolites, tCr, Glu, mIns and NAA and especially tCho appear as the most relevant markers for detection of focal metabolic alterations in epilepsy. Especially concerning cortical developmental alterations as a cause of epilepsy, our findings may have the potential to differentiate metabolic fingerprints for FCD subclasses.

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