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Abstract #0724

In vivo GABA increase as a biomarker of the epileptogenic zone: an unbiased metabolomics approach

Florence Fauvelle1,2, Vasile Stupar1,2, Jia Guo3, Wafae Labriji1, Chen Liu3, Alicia Plaindoux1, Emmanuel Luc Barbier1,2, Sophie Hamelin1, and Antoine Depaulis1
1Grenoble Institut Neurosciences, University Grenoble Alpes, La Tronche, France, 2IRMaGE, University Grenoble Alpes, La Tronche, France, 3Departement of Psychiatry, Columbia University, New York, NY, United States

New non invasive methods are required to better delimit the epileptogenic zone (EZ) during the pre-surgical exam of epileptic patients. By combining ex vivo NMR spectroscopy-based (MRS) untargeted metabolomics and in vivo MRS-based targeted metabolomics, we found that GABA was the most discriminant metabolite of the epileptogenic zone vs adjacent brain regions in a mouse model of mesio-temporal lobe epilepsy (MTLE). GABA appears therefore as a specific in vivo biomarker of EZ in MTLE.

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