Abstract #0724

In vivo GABA increase as a biomarker of the epileptogenic zone: an unbiased metabolomics approach

Florence Fauvelle^1,2, Vasile Stupar^1,2, Jia Guo³, Wafae Labriji¹, Chen Liu³, Alicia Plaindoux¹, Emmanuel Luc Barbier^1,2, Sophie Hamelin¹, and Antoine Depaulis¹

¹Grenoble Institut Neurosciences, University Grenoble Alpes, La Tronche, France, ²IRMaGE, University Grenoble Alpes, La Tronche, France, ³Departement of Psychiatry, Columbia University, New York, NY, United States

New non invasive methods are required to better delimit the epileptogenic zone (EZ) during the pre-surgical exam of epileptic patients. By combining ex vivo NMR spectroscopy-based (MRS) untargeted metabolomics and in vivo MRS-based targeted metabolomics, we found that GABA was the most discriminant metabolite of the epileptogenic zone vs adjacent brain regions in a mouse model of mesio-temporal lobe epilepsy (MTLE). GABA appears therefore as a specific in vivo biomarker of EZ in MTLE.

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