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Abstract #0733

JET - A Matlab toolkit for automated J-difference-edited MR spectra processing of in vivo mouse MEGA-PRESS study at 9.4T

Chen Liu1, David Jing Ma2, Nanyan Zhu3, Kay Igwe2, Jochen Weber2, Roshell Li4, Emily Turner Wood5, Wafae Labriji6, Vasile Stupar6, Yanping Sun7, Neil Harris8, Antoine Depaulis6, Florence Fauvelle 9, Scott A. Small10,11,12, Douglas L. Rothman13, and Jia Guo10,14
1Department of Electrical Engineering and the Taub Institute, Columbia University, New York, NY, United States, 2Columbia University, New York, NY, United States, 3Department of Biological Sciences and the Taub Institute, Columbia University, New York, NY, United States, 4Department of Biomedical Engineering, Columbia University, New York, NY, United States, 5University of California, Los Angeles, Los Angeles, CA, United States, 6Grenoble Institut Neurosciences (GIN), Grenoble, France, 7Herbert Irving Comprehensive Cancer Centre, Columbia University, New York, NY, United States, 8Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States, 9Grenoble MRI Facility IRMaGe, France, France, 10Department of Psychiatry, Columbia University, New York, NY, United States, 11Department of Neurology, Columbia University, New York, NY, United States, 12Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States, 13Radiology and Biomedical Imaging and of Biomedical Engineering, Yale University, New Haven, CT, United States, 14Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States

Spectral editing studies in mice brains have been limited due to difficulty in spectrum processing and lack of software package analysis. However, in preclinical studies, mouse models play an important role in understanding effects of drugs and its impact on the nervous system. JET is a fully automated software that performs raw data conversion, spectrum registration, spectral quality assessment and metabolite quantification of MEGA-PRESS mouse data at 9.4T. In this work, we first introduce the automated spectra processing pipeline of JET and further demonstrate its utilities in mouse studies.

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