Abstract #0733

JET - A Matlab toolkit for automated J-difference-edited MR spectra processing of in vivo mouse MEGA-PRESS study at 9.4T

Chen Liu¹, David Jing Ma², Nanyan Zhu³, Kay Igwe², Jochen Weber², Roshell Li⁴, Emily Turner Wood⁵, Wafae Labriji⁶, Vasile Stupar⁶, Yanping Sun⁷, Neil Harris⁸, Antoine Depaulis⁶, Florence Fauvelle ⁹, Scott A. Small^10,11,12, Douglas L. Rothman¹³, and Jia Guo^10,14

¹Department of Electrical Engineering and the Taub Institute, Columbia University, New York, NY, United States, ²Columbia University, New York, NY, United States, ³Department of Biological Sciences and the Taub Institute, Columbia University, New York, NY, United States, ⁴Department of Biomedical Engineering, Columbia University, New York, NY, United States, ⁵University of California, Los Angeles, Los Angeles, CA, United States, ⁶Grenoble Institut Neurosciences (GIN), Grenoble, France, ⁷Herbert Irving Comprehensive Cancer Centre, Columbia University, New York, NY, United States, ⁸Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States, ⁹Grenoble MRI Facility IRMaGe, France, France, ¹⁰Department of Psychiatry, Columbia University, New York, NY, United States, ¹¹Department of Neurology, Columbia University, New York, NY, United States, ¹²Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States, ¹³Radiology and Biomedical Imaging and of Biomedical Engineering, Yale University, New Haven, CT, United States, ¹⁴Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States

Spectral editing studies in mice brains have been limited due to difficulty in spectrum processing and lack of software package analysis. However, in preclinical studies, mouse models play an important role in understanding effects of drugs and its impact on the nervous system. JET is a fully automated software that performs raw data conversion, spectrum registration, spectral quality assessment and metabolite quantification of MEGA-PRESS mouse data at 9.4T. In this work, we first introduce the automated spectra processing pipeline of JET and further demonstrate its utilities in mouse studies.

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