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Abstract #0738

Validation and Application of a Novel Anisotropic MRE Reconstruction Method

Renee Miller1, Rob Lloyd2, Daniel Fovargue1, Behzad Babei2, Lauriane Juge2,3, Ralph Sinkus1, David Nordsletten1,4, and Lynne Bilston2,3
1Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom, 2Neuroscience Research Australia, Sydney, Australia, 3Faculty of Medicine, University of New South Wales, Sydney, Australia, 4University of Michigan, Ann Arbor, MI, United States

Due to their structure and composition, many biological tissues have been shown to be anisotropic. MRE, a non-invasive tool used to measure the stiffness of tissue, has previously been used to diagnose and track disease progression based on tissue stiffness changes. This work presents a robust and novel method for estimating anisotropic stiffness utilising harmonic displacements from MRE and material orientations from DTI. The method was verified using in silico experiments and applied to in vivo imaging data of the lower leg muscles in volunteers. In vivo stiffness estimates show changes in anisotropic stiffness with changes in passive muscle stretch.

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