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Abstract #0739

Relationships Between 7T Basal Ganglia QSM, Volume and Clinical Manifestation of Huntington’s Disease

Sivakami Avadiappan1, Melanie A Morrison1, Yicheng Chen1, Angela Jakary1, Nancy Cai2, Megan Casey2, Julia Glueck2, Joseph Tallakson2, Michael Geschwind2, Katherine Possin2, Alexandra Nelson2, Christopher P Hess1,2, and Janine M Lupo1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Huntington’s Disease (HD) is a neurodegenerative disorder with severe cognitive and motor impairment caused by abnormal cytosine-adenine-guanine (CAG) repeat expansion within the HTT gene. The goal of this study was to explore differences in iron deposition measured by quantitative susceptibility mapping (QSM) and volume of basal ganglia structures between healthy controls and patients with pre-manifest HD or early manifest HD and correlate them with clinical variables. The caudate and putamen exhibited atrophy that increased with disease severity, CAP score, and impaired motor function. Iron deposition increased with the onset of symptoms, CAP scores, and cognitive decline.

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