Abstract #0754

MP-Dixon-GRASP: Magnetization-Prepared Multiecho GRASP MRI for Free-Breathing Fat/Water-Separated 3D T1 Mapping

Li Feng¹, Fang Liu², Giorgios Soultanidis¹, Chenyu Liu¹, Thomas Benkert³, Sara Lewis¹, Kai Tobias Block^3,4, Zahi Fayad¹, and Yang Yang¹

¹Biomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³MR Application Development, Siemens Healthcare GmbH, Erlangen, Germany, ⁴Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

This study aims to develop a framework called MP-Dixon-GRASP (Magnetization-Prepared Dixon-based Golden-angle RAdial Sparse Parallel MRI) for rapid free-breathing fat/water-separated 3D T1 mapping of the liver. The technique combines inversion recovery-prepared multiecho stack-of-stars acquisition with subspace-based sparse image reconstruction. The performance of MP-Dixon-GRASP was evaluated in fat/water phantoms and in subjects with normal and elevated liver fat content. The results suggested that fat/water-separated T1 mapping is able to remove the influence of fat, which enables more accurate estimation of true T1 values in the liver. With fat/water-separated T1 estimation, MP-Dixon-GRASP could be potentially useful for imaging patients with fatty-liver diseases.

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