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Abstract #0754

MP-Dixon-GRASP: Magnetization-Prepared Multiecho GRASP MRI for Free-Breathing Fat/Water-Separated 3D T1 Mapping

Li Feng1, Fang Liu2, Giorgios Soultanidis1, Chenyu Liu1, Thomas Benkert3, Sara Lewis1, Kai Tobias Block3,4, Zahi Fayad1, and Yang Yang1
1Biomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3MR Application Development, Siemens Healthcare GmbH, Erlangen, Germany, 4Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

This study aims to develop a framework called MP-Dixon-GRASP (Magnetization-Prepared Dixon-based Golden-angle RAdial Sparse Parallel MRI) for rapid free-breathing fat/water-separated 3D T1 mapping of the liver. The technique combines inversion recovery-prepared multiecho stack-of-stars acquisition with subspace-based sparse image reconstruction. The performance of MP-Dixon-GRASP was evaluated in fat/water phantoms and in subjects with normal and elevated liver fat content. The results suggested that fat/water-separated T1 mapping is able to remove the influence of fat, which enables more accurate estimation of true T1 values in the liver. With fat/water-separated T1 estimation, MP-Dixon-GRASP could be potentially useful for imaging patients with fatty-liver diseases.

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