Abstract #0772

Pathological validation of MP-MRI intensity-based signatures in brain cancer patients using autopsy tissue samples

Samuel Bobholz¹, Allison Lowman², Michael Brehler², Savannah Duenweg¹, Fitzgerald Kyereme², Elizabeth Cochran³, Jennifer Connelly⁴, Wade Mueller⁵, Mohit Agarwal², Darren O'Neill², Anjishnu Banerjee⁶, and Peter LaViolette^2,7

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ³Pathology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, ⁷Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States

This study investigated the relationship between MRI-intensity values and pathological features of brain cancer using autopsy tissues as ground truth. Mixed effect models were used to examine the association between T1, T1C, FLAIR, and ADC intensity and pathological features (cellularity, cytoplasm density, and extracellular fluid density), as well as to compare the strength of these associations between GBM and non-GBM patients. These analyses confirmed many of the associations seen in prior literature, but with decreased strength than expected. Additionally, this study found that radio-pathomic associations were weaker in GBM patients than non-GBM patients.

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