Abstract #0773

Impact of inversion time for FLAIR acquisition on the T2-FLAIR mismatch detectability for IDH-mutant, non-CODEL astrocytomas

Manabu Kinoshita¹, Hideyuki Arita¹, Masamichi Takahashi², Takehiro Uda³, Junya Fukai⁴, Kenichi Ishibashi⁵, Noriyuki Kijima¹, Ryuichi Hirayama¹, Mio Sakai⁶, Atsuko Arisawa⁷, Hiroto Takahashi⁷, Katsuyuki Nakanishi⁶, Naoki Kagawa¹, Kouichi Ichimura⁸, Yonehiro Kanemura⁹, Yoshitaka Narita², and Haruhiko Kishima¹

¹Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan, ³Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Neurological Surgery, Wakayama Medical University, Wakayama, Japan, ⁵Neurosurgery, Osaka City General Hospital, Osaka, Japan, ⁶Diagnostic Radiology, Osaka International Cancer Institute, Osaka, Japan, ⁷Radiology, Osaka University Graduate School of Medicine, Suita, Japan, ⁸Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan, ⁹Biomedical Research and Innovation, National Hospital Organization Osaka National Hospital, Osaka, Japan

Although the T2-FLAIR mismatch sign is a promising imaging marker specific for IDHmt, non-CODEL astrocytomas, its low sensitivity and NPV hinder its full clinical application. This study discovered that FLAIR acquisition with TI shorter than 2400 ms in 3T could overcome this issue and that the sensitivity and NPV improved to 67% and 74%. Tuning TI for FLAIR acquisition is such a simple technique that clinicians can easily incorporate this procedure into the daily workflow of glioma imaging. Our proposed method would provide a novel yet clinically feasible glioma imaging method in the era of personalized-molecular medicine of cancer.

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