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Abstract #0773

Impact of inversion time for FLAIR acquisition on the T2-FLAIR mismatch detectability for IDH-mutant, non-CODEL astrocytomas

Manabu Kinoshita1, Hideyuki Arita1, Masamichi Takahashi2, Takehiro Uda3, Junya Fukai4, Kenichi Ishibashi5, Noriyuki Kijima1, Ryuichi Hirayama1, Mio Sakai6, Atsuko Arisawa7, Hiroto Takahashi7, Katsuyuki Nakanishi6, Naoki Kagawa1, Kouichi Ichimura8, Yonehiro Kanemura9, Yoshitaka Narita2, and Haruhiko Kishima1
1Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan, 2Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan, 3Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 4Neurological Surgery, Wakayama Medical University, Wakayama, Japan, 5Neurosurgery, Osaka City General Hospital, Osaka, Japan, 6Diagnostic Radiology, Osaka International Cancer Institute, Osaka, Japan, 7Radiology, Osaka University Graduate School of Medicine, Suita, Japan, 8Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan, 9Biomedical Research and Innovation, National Hospital Organization Osaka National Hospital, Osaka, Japan

Although the T2-FLAIR mismatch sign is a promising imaging marker specific for IDHmt, non-CODEL astrocytomas, its low sensitivity and NPV hinder its full clinical application. This study discovered that FLAIR acquisition with TI shorter than 2400 ms in 3T could overcome this issue and that the sensitivity and NPV improved to 67% and 74%. Tuning TI for FLAIR acquisition is such a simple technique that clinicians can easily incorporate this procedure into the daily workflow of glioma imaging. Our proposed method would provide a novel yet clinically feasible glioma imaging method in the era of personalized-molecular medicine of cancer.

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