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Abstract #0774

Leakage Correction of Dynamic Susceptibility Contrast (DSC-) MRI for vessel size measurements in human glioma

Fatemeh Arzanforoosh1, Paula L. Croal2, Karin Van Garderen1, Marion Smits1, Michael A. Chappell2, and Esther A.H. Warnert1
1Department of Radiology & Nuclear Medicine, ErasmusMC, Rotterdam, Netherlands, 2Radiological Sciences, Division of Clinical Neurosciences, University of Nottingham, Nottingham, United Kingdom

Reliable insight about tumor microvasculature is important for monitoring of disease progression and treatment response. Derived from Dynamic Susceptibility Contrast MRI, transverse relaxation rates are used for vessel size estimation. In high grade glioma, these signals can artificially change by contrast agent extravasation through a disrupted Blood-Brain-Barrier. In this study the effect of applying Boxerman-Schmainda-Weisskoff leakage correction on vessel size estimation has been investigated on a group of 12 glioma patients. The result shows that in Contrast-Enhanced Tumor area applying leakage correction significantly and noticeably changes the vessel size measurements.

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