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Abstract #0776

MR Imaging Parameters for Noninvasive Prediction of EGFR Amplification in IDH-Wildtype Lower-Grade Gliomas: A Multicenter Study

Yae Won Park1, Ji Eun Park2, Sung Soo Ahn1, Seung Hong Choi3, Ho Sung Kim2, and Seung-Koo Lee1
1Yonsei University College of Medicine, Seoul, Korea, Republic of, 2University of Ulsan College of Medicine, Seoul, Korea, Republic of, 3Seoul National University Hospital, Seoul, Korea, Republic of

Epidermal growth factor receptor (EGFR) amplification status of isocitrate dehydrogenase-wildtype (IDHwt) lower-grade gliomas (LGGs; grade II/III) is one of the key molecular markers for diagnosing molecular glioblastoma. Our study shows that infiltrative or mixed pattern, lower ADC, lower 5th percentile of ADC, and higher 95th percentile of nCBF may be useful imaging biomarkers for the EGFR amplification of IDHwt LGGs. Moreover, quantitative imaging biomarkers may add value to qualitative imaging parameters (with AUCs of 0.71 and 0.88, p = 0.020).

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