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Abstract #0786

Uniform Magnetization Transfer contrast at 7T with Direct Saturation Control

David Leitão1, Raphael Tomi-Tricot2, Pip Bridgen1, Tom Wilkinson1, Patrick Liebig3, Rene Gumbrecht3, Dieter Ritter3, Sharon Giles1, Ana Baburamani1, Jan Sedlacik1, Joseph V. Hajnal1,4, and Shaihan J. Malik1,4
1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Centre for the Developing Brain, King's College London, London, United Kingdom

Conventional RF pulse design methods optimize for rotation of the magnetization. However, in systems with Magnetization Transfer (MT) with a semisolid pool, the dynamics do not follow the Bloch equations; saturation of the semisolid depends on |B1+|2, making it particularly sensitive to B1+ inhomogeneities. This work employs a novel pulse design framework termed ‘Direct Saturation Control’ (DSatC) to directly consider semisolid saturation. We use this to design composite pulses with spatially uniform semisolid saturation using parallel transmition at 7T, where B1+ is intrinsically highly inhomogeneous. In-vivo results show much more homogeneous MT contrast when using DSatC.

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