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Abstract #0791

Genetic associations of magnetic susceptibility in the brain

Chaoyue Wang1, Benjamin C. Tendler1, Stephen M. Smith1, Fidel Alfaro-Almagro1, Alberto Llera2, Cristiana Fiscone3,4, Richard Bowtell3, Lloyd T. Elliott5, Karla L. Miller1, and Aurea B. Martins-Bach1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands, 3Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 4Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 5Department of Statistics and Actuarial Science, Simon Fraser University, Vancouver, BC, Canada

UK Biobank is scanning 100,000 participants using multi-modal MRI (including swMRI). This rich resource also includes genome-wide characterisation of individuals. This provides a powerful opportunity to relate swMRI-derived measures to genetics. The aim of this work is to identify genetic associations of QSM-based measures. We carried out genome-wide association studies (GWAS) in over 30,000 subjects for both QSM and T2* based measures. Our results demonstrate that susceptibility and T2* measures are associated with genetic loci involved in a range of biological functions. Susceptibility and T2* IDPs share many common genetic associations but there are also complementary associations.

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