Abstract #0791

Genetic associations of magnetic susceptibility in the brain

Chaoyue Wang¹, Benjamin C. Tendler¹, Stephen M. Smith¹, Fidel Alfaro-Almagro¹, Alberto Llera², Cristiana Fiscone^3,4, Richard Bowtell³, Lloyd T. Elliott⁵, Karla L. Miller¹, and Aurea B. Martins-Bach¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands, ³Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁴Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ⁵Department of Statistics and Actuarial Science, Simon Fraser University, Vancouver, BC, Canada

UK Biobank is scanning 100,000 participants using multi-modal MRI (including swMRI). This rich resource also includes genome-wide characterisation of individuals. This provides a powerful opportunity to relate swMRI-derived measures to genetics. The aim of this work is to identify genetic associations of QSM-based measures. We carried out genome-wide association studies (GWAS) in over 30,000 subjects for both QSM and T2* based measures. Our results demonstrate that susceptibility and T2* measures are associated with genetic loci involved in a range of biological functions. Susceptibility and T2* IDPs share many common genetic associations but there are also complementary associations.

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