Abstract #0797

Native Contrast Visualization of Myocardial Radiofrequency Ablation and Acetic Acid Chemoablation Lesions at 0.55 T

Daniel Herzka¹, Chris G. Bruce¹, Rajiv Ramasawmy¹, D. Korel A Yildirim¹, Kendall J. O'Brien¹, William H. Schenke¹, Toby Rogers^1,2, Adrienne E. Campbell-Washburn^1,3, Robert J. Lederman ¹, and Aravindan Kolandaivelu^1,4

¹NHLBI, Division of Intramural Research, National Institutes of Health, Bethesda, MD, United States, ²Department of Cardiology, Medstar Washington Hospital Center, Washington, DC, United States, ³Biophysics and Biochemistry Branch, Division of Intramural Research, National Institutes of Health, Bethesda, MD, United States, ⁴Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

This work determined feasibility of visualizing cardiac radiofrequency (RF) ablation lesions at low field (0.55 T) as well as a novel alternative method for targeted tissue destruction: acetic acid chemoablation. Native contrast T1-W imaging and T1 mapping and were carried out in vivo in swine on the day of ablation. Ex vivo high-resolution imaging and histology were used as references. T1 drop was higher for chemoablation (40%) than for RF ablation (19%) relative to myocardium, resulting in significantly higher SNR and CNRs. The visualization of coagulation necrosis from cardiac ablation is feasible using native-contrast low-field MRI.

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