Abstract #0796

QSMART: a parallel stage QSM pipeline for suppression of cortical and venous artifacts

Negin Yaghmaie^1,2, Warda Syeda^3,4, Chengchuan Wu^1,2, Yicheng Zhang^1,2, Bradford A. Moffat^1,4, Rebecca Glarin^1,5, Scott Kolbe^4,6,7, and Leigh Johnston^1,2

¹Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Australia, ²Department of Biomedical Engineering, The University of Melbourne, Melbourne, Australia, ³Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia, ⁴Department of Medicine and Radiology, The University of Melbourne, Melbourne, Australia, ⁵Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia, ⁶Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia, ⁷Department of Radiology, Alfred Hospital, Melbourne, Australia

We propose a two-stage QSM method, Quantitative Susceptibility Mapping Artifact Reduction Technique (QSMART), in which tissue and vein susceptibility values are estimated in parallel by generating a vasculature mask from the magnitude data using a Frangi filter. Spatially Dependent Filtering is employed for the background field removal and the two susceptibility estimates are combined in the final QSM map. QSMART is compared to RESHARP/iLSQR and V-SHARP/iLSQR inversion on 7T in vivo single and multiple-orientation scans. QSMART demonstrates superior artifact suppression in the cortex and near vasculature, and is a robust tool for susceptibility estimation. QSMART code is available at https://github.com/MBCIU/QSMART.

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