Abstract #0799

A Daily Quantitative Brain MRI Protocol for the 1.5 T MR-Linac: Feasibility of CEST with Preliminary Results on a Prospective Imaging Study

Rachel W. Chan¹, Liam S.P. Lawrence², Ryan T. Oglesby², Hanbo Chen³, Brian Keller³, James Stewart³, Mark Ruschin³, Brige Chugh^3,4, Scott MacKenzie³, Mikki Campbell³, Aimee Theriault³, Sten Myrehaug³, Jay Detsky³, Pejman J. Maralani⁵, Chia-Lin Tseng³, Gregory J. Czarnota^1,2,3, Greg J. Stanisz^1,2,6, Arjun Sahgal³, and Angus Z. Lau^1,2

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Physics, Ryerson University, Toronto, ON, Canada, ⁵University of Toronto, Sunnybrook Health Sciences Centre, Medical Imaging, Toronto, ON, Canada, ⁶Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

A multi-parametric imaging protocol, for monitoring patients with brain tumors treated using the 1.5T MR-Linac radiotherapy system, is presented with a focus on CEST. Phantom experiments were performed on the MR-Linac using varying concentrations of ammonium chloride mixtures. 24 subjects were included in the analysis. Mixed modelling was used to determine any differences between the gross tumor volume (GTV) and contralateral normal appearing white matter (cNAWM) regions, where three CEST parameters were investigated (MTR_Amide, MTR_NOE and Asymmetry). Results from phantom experiments confirmed detectable CEST asymmetry. Significant differences were found in all three CEST parameters between the GTV and cNAWM.

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