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Abstract #0799

A Daily Quantitative Brain MRI Protocol for the 1.5 T MR-Linac: Feasibility of CEST with Preliminary Results on a Prospective Imaging Study

Rachel W. Chan1, Liam S.P. Lawrence2, Ryan T. Oglesby2, Hanbo Chen3, Brian Keller3, James Stewart3, Mark Ruschin3, Brige Chugh3,4, Scott MacKenzie3, Mikki Campbell3, Aimee Theriault3, Sten Myrehaug3, Jay Detsky3, Pejman J. Maralani5, Chia-Lin Tseng3, Gregory J. Czarnota1,2,3, Greg J. Stanisz1,2,6, Arjun Sahgal3, and Angus Z. Lau1,2
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Department of Physics, Ryerson University, Toronto, ON, Canada, 5University of Toronto, Sunnybrook Health Sciences Centre, Medical Imaging, Toronto, ON, Canada, 6Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

A multi-parametric imaging protocol, for monitoring patients with brain tumors treated using the 1.5T MR-Linac radiotherapy system, is presented with a focus on CEST. Phantom experiments were performed on the MR-Linac using varying concentrations of ammonium chloride mixtures. 24 subjects were included in the analysis. Mixed modelling was used to determine any differences between the gross tumor volume (GTV) and contralateral normal appearing white matter (cNAWM) regions, where three CEST parameters were investigated (MTRAmide, MTRNOE and Asymmetry). Results from phantom experiments confirmed detectable CEST asymmetry. Significant differences were found in all three CEST parameters between the GTV and cNAWM.

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