Abstract #0800

Spectroscopic MRI Guided Radiation Dose Escalation in Glioblastoma Patients

Mohammed Z Goryawala¹, Eric A Mellon², Saumya Gurbani³, Karthik Ramesh³, Brent D Weinberg⁴, Lawrence Kleinberg⁵, Eduard Schreibmann³, Sulaiman Sheriff¹, Peter B. Barker⁶, Shu Hui-Kuo⁷, Hyunsuk Shim³, and Andrew Maudsley⁸

¹Radiology, University of Miami School of Medicine, Miami, FL, United States, ²Radiation Oncology, University of Miami School of Medicine, Miami, FL, United States, ³Emory University, Atlanta, GA, United States, ⁴Radiology, Emory University, Atlanta, GA, United States, ⁵Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States, ⁶Radiology, Johns Hopkins University, Baltimore, MD, United States, ⁷Radiation Oncology, Emory University, Atlanta, GA, United States, ⁸Radiology, University of Miami, School of Medicine, Miami, FL, United States

To improve localization of tumor tissue for radiation treatment planning a volumetric MR spectroscopic imaging acquisition was used to identify regions of metabolic abnormality. These regions were then integrated into the clinical treatment plan to target increased radiation dose for the identified volume. In a 3-site clinical trial of 30 patients with newly-diagnosed glioblastoma, the escalated dose resulted in a median overall survival of 23 months, which compares favorably with standard of care, without severe adverse events. This study demonstrates considerable potential for incorporating volumetric spectroscopic imaging into radiation treatment planning protocols.

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