Abstract #0801

Technical feasibility and imaging of transcranial MR-guided in-vivo Histotripsy treatment

Dinank Gupta¹, Ning Lu¹, Adam Fox¹, Dave Choi¹, Jonathan Sukovich¹, Badih Junior Daou², Aditya Pandey², Timothy Hall¹, Zhen Xu¹, and Douglas Noll¹

¹Biomedical Engineering, The University of Michigan, Ann Arbor, MI, United States, ²Department of Neurosurgery, The University of Michigan, Ann Arbor, MI, United States

Feasibility of transcranial MR-guided histotripsy for an in-vivo large animal model is established. Eight juvenile pigs were treated using an in-house, 128 channel histotripsy array at a wide range of sites around the brain. Target localization was done using fiducials placed on the array using pre-treatment MR images. Lesions were generated in all the pigs and were visualized in post treatment MRI scans and histology. In acute treatment phase, treatment effects were visible on T2*,T2, T1/T2 FLAIR weighted images. This is the first study to exhibit feasibility of in-vivo transcranial MR-guided histotripsy treatment.

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