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Abstract #0801

Technical feasibility and imaging of transcranial MR-guided in-vivo Histotripsy treatment

Dinank Gupta1, Ning Lu1, Adam Fox1, Dave Choi1, Jonathan Sukovich1, Badih Junior Daou2, Aditya Pandey2, Timothy Hall1, Zhen Xu1, and Douglas Noll1
1Biomedical Engineering, The University of Michigan, Ann Arbor, MI, United States, 2Department of Neurosurgery, The University of Michigan, Ann Arbor, MI, United States

Feasibility of transcranial MR-guided histotripsy for an in-vivo large animal model is established. Eight juvenile pigs were treated using an in-house, 128 channel histotripsy array at a wide range of sites around the brain. Target localization was done using fiducials placed on the array using pre-treatment MR images. Lesions were generated in all the pigs and were visualized in post treatment MRI scans and histology. In acute treatment phase, treatment effects were visible on T2*,T2, T1/T2 FLAIR weighted images. This is the first study to exhibit feasibility of in-vivo transcranial MR-guided histotripsy treatment.

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