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Abstract #0802

MR-Guided Blood-brain Barrier Opening Induced by Rapid Short-pulse Ultrasound on Non-human Primates

Hui Zhou1,2, Yang Liu3, Xiaojing Long3, Yangzi Qiao1, Jo Lee1, Chao Zou1,4, Xin Liu1,4, and Hairong Zheng1
1Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2The Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, shenzhen, China, 3Research center for medical AI´╝îShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 4Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China

The BBB has been opened with millisecond ultrasound in kinds of animals for researching of neurological diseases therapy. Rapid short-pulse (RaSP) ultrasound with a microsecond sequence has been proposed as a minimally disruptive and efficient method for BBB opening in mice and rats. This work quantitatively evaluate the feasibility and safety of BBB opening in non-human primate with RaSP by contrast enhanced MRI. The relative signal enhancement in RaSP with 6% energy deposition reached more than 60% of that with 10 ms long pulse (LP), which shows that RaSP is a practical method for BBB opening in a large-animal model.

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