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Abstract #0823

Evaluation of primary and secondary collateral pathways in carotid artery stenosis patients before and after revascularization therapy

Lena Schmitzer1, Alexander Seiler2, Nico Sollmann1, Christine Preibisch1,3, Kilian Weiss4, Claus Zimmer1, Fahmeed Hyder5, Jens Göttler1,5, and Stephan Kaczmarz1,5
1School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany, 3School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany, 4Philips Healthcare, Hamburg, Germany, 5MRRC, Yale University, New Haven, CT, United States

Internal carotid artery stenosis (ICAS) is a well-known risk factor for stroke. While collaterals play a pivotal role in ischemic stroke, their effects in ICAS are not entirely understood. We assessed primary collaterals, i.e., configuration of the Circle of Willis by MR-Angiography, and high Coefficients of Variance in Dynamic Susceptibility Contrast MRI as surrogate of secondary collaterals. Moreover, individual watershed areas (iWSA) were determined in a group of ICAS patients and healthy volunteers. Our results demonstrate post-interventional shifts of iWSA, mainly influenced by primary collateral flow. No secondary collateral flow was found in patients similar to age-matched healthy participants.

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