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Abstract #0825

Evaluation of leptomeningeal collaterals by DSC-based signal variance and hemodynamic features in asymptomatic carotid artery stenosis

Stephan Kaczmarz1,2, Lena Schmitzer1, Jens Göttler1,2, Kilian Weiss3, Christian Sorg1, Claus Zimmer1, Fahmeed Hyder2, Christine Preibisch1, and Alexander Seiler4
1School of Medicine, Department of Neuroradiology, Technical University of Munich (TUM), Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3Philips Healthcare, Hamburg, Germany, 4Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany

Detection of leptomeningeal collateral blood flow has high clinical relevance, but clinically applicable imaging methods are lacking. While a novel approach based on coefficient of variance (CoV) analysis of dynamic susceptibility contrast (DSC) MRI was recently proposed, relations to hemodynamic alterations remained unknown. Moreover, the role of leptomeningeal collaterals in internal carotid artery stenosis (ICAS) is under debate. We present multi-parametric hemodynamic evaluation within high CoV-voxels from 29 asymptomatic ICAS-patients and 30 age-matched healthy controls. Our results suggest no enhanced leptomeningeal collateral recruitment in asymptomatic ICAS. However, hemodynamic characteristics imply detection of voxels that are prone to future leptomeningeal recruitment.

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