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Abstract #0830

Characterization of radiological findings in mouse models of cerebral small vessel diseases using multimodal MRI at 14.1 Tesla

Xiao Gao1, Xiaowei Wang2, Kai Qiao1, Cassandre Labelle-Dumais2, Douglas Gould2, and Myriam M. Chaumeil1
1Department of Radiology, University of California, San Francisco, San Francisco, CA, United States, 2Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, United States

Cerebral small vessel diseases (cSVDs) are a group of conditions that account for up to 30% of strokes. Clinical manifestations associated with cSVD include blood–brain barrier (BBB) leakage, microbleeds, and white matter lesions. Here, we use multimodal MRI at 14.1Tesla to characterize radiological findings observed in innovative mouse models of cSVD caused by mutations in Collagen type IV alpha 1 (Col4a1). By leveraging several image processing toolboxes, we established a workflow that could successfully differentiate between disease subtypes based on the spatial distribution and volume of lesions.

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