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Abstract #0831

Mechanisms of cerebral ischemic stroke recovery from stem cell derived therapies assessed via MRI at 21.1 T

Shannon Helsper1,2, Xuegang Yuan1,2, and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study evaluates therapeutic efficacy of human mesenchymal stem cell (hMSC) derived treatments applied to an ischemic stroke rat model. The goal is to determine if the presence of hMSC or hMSC derivatives in an ischemic region is required or if delivery of cell secretions alone can improve outcomes, either locally at the lesion or by recruiting regenerative neural progenitor cells. Biochemical markers of tissue recovery measured longitudinally using sodium chemical shift imaging and relaxation-enhanced MR spectroscopy at 21.1 T enables increased sensitivity, enabling insight into ionic and metabolic regulation while enabling to determine therapy efficacy.

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