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Abstract #0832

Mesenchymal Stem Cell Impacts on Cerebral Microstructural Diffusion Recovery After Ischemic Attack

Frederick A Bagdasarian1,2, Xuegang Yuan1,2, and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

DTI, NODDI and DKI techniques were applied to diffusion data acquired at 21.1 T to identify microtissue changes in ischemic brain tissue following adult human mesenchymal stem cell (hMSC) or control treatment. Scanning was conducted 1-21 d post-MCAO and treatment. 2D hMSC significantly reduced cell swelling (ICVF) at nearly every time-point in white matter while preserving orientation integrity (ODI), normal levels of DTI metrics, and early phase kurtosis. In grey matter, 2D hMSC restored DTI metrics to naïve levels quicker than control treatments, as did ICVF and ODI. Kurtosis had high variability, with minor trends evident.

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