Abstract #0847

Differences in distribution of MRI-based fat fraction in lower limb skeletal muscles of six different neuromuscular disorders

Harmen Reyngoudt^1,2, Pierre-Yves Baudin^1,2, Ericky C.A. Araujo^1,2, Pierre G. Carlier³, and Benjamin Marty^1,2

¹NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, ²NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, ³CEA, DRF, Service Hospitalier Frédéric Joliot, Orsay, France

Quantitative MRI fat-water separation techniques such as Dixon are often used to evaluate disease progression in muscle of neuromuscular diseases. Although the mean fat fraction (FF) value per region of interest (ROI) is a valuable objective MRI biomarker, it does not reflect the variation of FF within this ROI. In this study we analyzed 6582 muscle ROIs in leg and thigh of 6 different neuromuscular diseases and analyzed, besides the mean FF, other statistical metrics such as median, standard deviation, kurtosis and skewness. The differences in FF distribution might reveal additional information about the individual patient’s disease evolution.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.