Abstract #0848

Tumor T1 for early chemotherapeutic response evaluation in patients with osteosarcoma with correlation to histological necrosis

Esha Baidya Kayal¹, Nikhil Sharma¹, Raju Sharma², Sameer Bakhshi³, Devasenathipathy Kandasamy², and Amit Mehndiratta^1,4

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Radio diagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, ⁴Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

The spin relaxation time (T1) of the water protons, an intrinsic property of tissue, can be a useful marker of therapeutic response in osteosarcoma. T1 values were estimated in whole tumor volume before and after completion of chemotherapy and histogram analysis was performed to characterize tumor T1 and its changes in the course of chemotherapy. Results showed mean and skewness of T1 relaxation time in tumor may be useful as non-invasive imaging markers of chemotherapeutic response in osteosarcoma.

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