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Abstract #0864

New insights from the IronTract challenge: Simple post-processing enhances the accuracy of diffusion tractography

Chiara Maffei1, Gabriel Girard2,3,4, Kurt G. Schilling5, Dogu Baran Aydogan6, Nagesh Adluru7, Andrey Zhylka8, Ye Wu9, Matteo Mancini10,11,12, Andac Hamamci13, Alessia Sarica14, Davood Karimi15, Fang-Cheng Yeh16, Mert E. Yildiz13, Ali Gholipour15, Andrea Quattrone17, Aldo Quattrone14, Pew-Thian Yap9, Alberto de Luca18,19, Josien Pluim8, Alexander Lemans18, Vivek Prabhakaran7, Barbara B. Bendlin7, Andrew L. Alexander7, Bennett A. Landman5, Erick J. Canales-Rodríguez4, Muhamed Barakovic20, Jonathan Rafael-Patino4, Thomas Yu4, Gaëtan Rensonnet4, Simona Schiavi21, Alessandro Daducci21, Marco Pizzolato4,22, Elda Fischi-Gomez4, Jean-Philippe Thiran2,3,4, George Dai23, Giorgia Grisot24, Santi Puch25, Marc Ramos25, Nikola Lazovski25, Paulo Rodrigues25, Vesna Prchkovska25, Robert Jones1, Julia Lehman26, Suzanne Haber26, and Anastasia Yendiki1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3CIBM Center for BioMedical Imaging, Lausanne, Switzerland, 4École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 5Vanderbilt University, Nashville, TN, United States, 6Aalto University School of Science, Espoo, Finland, 7University of Wisconsin, Madison, WI, United States, 8Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 9Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapell Hill, NC, United States, 10Department of Neuroscience, Brighton and Sussex Medical School University of Sussex, Brighton, United Kingdom, 11CUBRIC, Cardiff University, Cardiff, United Kingdom, 12NeuroPoly, Polytechnique Montreal, Montreal, QC, Canada, 13Department of Biomedical Engineering, Faculty of Engineering, Yeditepe University, Instanbul, Turkey, 14Neuroscience Research Center, University “Magna Graecia”, Catanzaro, Italy, 15Computational Radiology Laboratory, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 16Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States, 17Institute of Neurology, University “Magna Graecia”, Catanzaro, Italy, 18Imaging Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 19Neurology Department, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, 20University of Basel, Basel, Switzerland, 21University of Verona, Verona, Italy, 22Technical University of Denmark, Kongens Lyngby, Denmark, 23Wellesley College, Wellesley, MA, United States, 24DeepHealth, Inc., Cambridge, MA, United States, 25QMENTA, Inc., Barcelona, Spain, 26Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY, United States

We present results from round 2 of IronTract, the first challenge to evaluate the accuracy of tractography using i) tracer injections and diffusion MRI from the same macaque brains, and ii) DSI and HCP two-shell diffusion acquisition schemes. In round 1, only two teams achieved similarly high performance between the two different injection sites that we used for training and validation. Here we investigate the extent to which this was due to the pre- and post-processing used by those teams. We show that, when other teams use the same pre- and post-processing, their accuracy and robustness can improve as well.

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