Abstract #0864

New insights from the IronTract challenge: Simple post-processing enhances the accuracy of diffusion tractography

Chiara Maffei¹, Gabriel Girard^2,3,4, Kurt G. Schilling⁵, Dogu Baran Aydogan⁶, Nagesh Adluru⁷, Andrey Zhylka⁸, Ye Wu⁹, Matteo Mancini^10,11,12, Andac Hamamci¹³, Alessia Sarica¹⁴, Davood Karimi¹⁵, Fang-Cheng Yeh¹⁶, Mert E. Yildiz¹³, Ali Gholipour¹⁵, Andrea Quattrone¹⁷, Aldo Quattrone¹⁴, Pew-Thian Yap⁹, Alberto de Luca^18,19, Josien Pluim⁸, Alexander Lemans¹⁸, Vivek Prabhakaran⁷, Barbara B. Bendlin⁷, Andrew L. Alexander⁷, Bennett A. Landman⁵, Erick J. Canales-Rodríguez⁴, Muhamed Barakovic²⁰, Jonathan Rafael-Patino⁴, Thomas Yu⁴, Gaëtan Rensonnet⁴, Simona Schiavi²¹, Alessandro Daducci²¹, Marco Pizzolato^4,22, Elda Fischi-Gomez⁴, Jean-Philippe Thiran^2,3,4, George Dai²³, Giorgia Grisot²⁴, Santi Puch²⁵, Marc Ramos²⁵, Nikola Lazovski²⁵, Paulo Rodrigues²⁵, Vesna Prchkovska²⁵, Robert Jones¹, Julia Lehman²⁶, Suzanne Haber²⁶, and Anastasia Yendiki¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³CIBM Center for BioMedical Imaging, Lausanne, Switzerland, ⁴École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Vanderbilt University, Nashville, TN, United States, ⁶Aalto University School of Science, Espoo, Finland, ⁷University of Wisconsin, Madison, WI, United States, ⁸Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁹Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapell Hill, NC, United States, ¹⁰Department of Neuroscience, Brighton and Sussex Medical School University of Sussex, Brighton, United Kingdom, ¹¹CUBRIC, Cardiff University, Cardiff, United Kingdom, ¹²NeuroPoly, Polytechnique Montreal, Montreal, QC, Canada, ¹³Department of Biomedical Engineering, Faculty of Engineering, Yeditepe University, Instanbul, Turkey, ¹⁴Neuroscience Research Center, University “Magna Graecia”, Catanzaro, Italy, ¹⁵Computational Radiology Laboratory, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ¹⁶Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States, ¹⁷Institute of Neurology, University “Magna Graecia”, Catanzaro, Italy, ¹⁸Imaging Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Neurology Department, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, ²⁰University of Basel, Basel, Switzerland, ²¹University of Verona, Verona, Italy, ²²Technical University of Denmark, Kongens Lyngby, Denmark, ²³Wellesley College, Wellesley, MA, United States, ²⁴DeepHealth, Inc., Cambridge, MA, United States, ²⁵QMENTA, Inc., Barcelona, Spain, ²⁶Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY, United States

We present results from round 2 of IronTract, the first challenge to evaluate the accuracy of tractography using i) tracer injections and diffusion MRI from the same macaque brains, and ii) DSI and HCP two-shell diffusion acquisition schemes. In round 1, only two teams achieved similarly high performance between the two different injection sites that we used for training and validation. Here we investigate the extent to which this was due to the pre- and post-processing used by those teams. We show that, when other teams use the same pre- and post-processing, their accuracy and robustness can improve as well.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.