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Abstract #0865

Investigating the Occurrence of Asymmetric Patterns in White Matter Fiber Orientation Distribution Functions

Charles Poirier1, √Čtienne St-Onge1, and Maxime Descoteaux1
1Sherbrooke Connectivity Imaging Laboratory (SCIL), Université de Sherbrooke, Sherbrooke, QC, Canada

In general, fiber orientation distribution functions are defined as symmetric spherical functions. The present work shows how local averaging can be used to compute averaged asymmetric fODF (ava-fODF) from input symmetric white matter (WM) fODF. The resulting ava-fODF shows the presence of asymmetric patterns in voxels containing multiple crossings as well as along the white matter/gray matter interface. Moreover, the proportion of WM voxels displaying asymmetric features after filtering accounts for at least 30% of all WM voxels. Ava-fODF reveals new possibilities for classification of fiber configurations, with unidirectional fODF, bending fODF, Y-branching fODF and other complex fiber configurations.

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