Abstract #0870

Pseudo-Continuous Arterial Spin Labeling using Multiple Label- and Post-Label Duration with Dynamically Optimized Background Suppression

Makoto Obara¹, Osamu Togao², Tatsuhiro Wada³, Chiaki Tokunaga³, Ryoji Mikayama³, Hiroshi Hamano¹, Kim van de Ven⁴, Masami Yoneyama¹, Tetsuo Ogino¹, Yuta Akamine¹, Yu Ueda¹, Jihun Kwon¹, and Marc Van Cauteren⁵

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, ⁴Philips Healthcare, Best, Netherlands, ⁵Philips Healthcare, Tokyo, Japan

The arterial transit time (ATT) calculated from multiple time points pseudo continuous arterial spin labeling (pCASL) has recently attracted attention. To calculate ATT accurately, while ensuring reliable SNR, we propose multiple repetition time (multi-TR) scheme, that is TR is varied according to the label duration (LD) and post label delay (PLD) with dynamically optimized BGS and 3D acquisition. The multi points data is efficiently acquired and scan time is less than 3 minutes for whole brain coverage. We conducted a feasibility test. Reliable background suppression effectiveness for all time points and a significant SNR gain were confirmed in healthy volunteers.

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