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Abstract #0870

Pseudo-Continuous Arterial Spin Labeling using Multiple Label- and Post-Label Duration with Dynamically Optimized Background Suppression

Makoto Obara1, Osamu Togao2, Tatsuhiro Wada3, Chiaki Tokunaga3, Ryoji Mikayama3, Hiroshi Hamano1, Kim van de Ven4, Masami Yoneyama1, Tetsuo Ogino1, Yuta Akamine1, Yu Ueda1, Jihun Kwon1, and Marc Van Cauteren5
1Philips Japan, Tokyo, Japan, 2Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, 4Philips Healthcare, Best, Netherlands, 5Philips Healthcare, Tokyo, Japan

The arterial transit time (ATT) calculated from multiple time points pseudo continuous arterial spin labeling (pCASL) has recently attracted attention. To calculate ATT accurately, while ensuring reliable SNR, we propose multiple repetition time (multi-TR) scheme, that is TR is varied according to the label duration (LD) and post label delay (PLD) with dynamically optimized BGS and 3D acquisition. The multi points data is efficiently acquired and scan time is less than 3 minutes for whole brain coverage. We conducted a feasibility test. Reliable background suppression effectiveness for all time points and a significant SNR gain were confirmed in healthy volunteers.

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